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Chronic Fatigue

What is ME/CFS?

ME/CFS is the acronym for Myalgic Encephalomyelitis or Myalgic Encephalopathy / Chronic Fatigue Syndrome, a condition that has never been properly named. The disease has had many names, including: post-viral fatigue syndrome, low natural killer cell disease, chronic Epstein-Barr virus syndrome, chronic fatigue and immune dysfunction syndrome (CFIDS), and the insulting Yuppie flu.

While all diagnosed ME/CFS patients are “functionally impaired by definition,” according to the Centers for Disease Control, the CDC studies indicate the illness can be as disabling as multiple sclerosis, lupus, rheumatoid arthritis, heart disease, chronic obstructive pulmonary disease, or end-stage (terminal) renal failure.

ME/CFS is also a relapsing, remitting illness that often follows a cyclical course. Typically the ME/CFS patient’s fatigue is made worse by either physical or mental activity, so that giving in to the temptation to overdo is repaid by “post-exertional malaise” (extreme, prolonged exhaustion and a worsening of symptoms following physical or mental exertion). The worse the illness, the less activity is possible. Indeed, the first means of testing objectively for ME/CFS may be a “Two-day Exercise Test” demonstrating diminished cardiopulmonary capacity in patients on the day following an initial exercise test.


The symptoms of ME/CFS are variable and unique to each sufferer. The overriding symptom is one of debilitating unexplained fatigue that lasts longer than six months. This fatigue significantly reduces activities of daily living including work, school, social, and personal activities. The fatigue is made worse by any exertion and not relieved by rest.

Other primary symptoms may include:

  • Post-exertional malaise lasting more than 24 hours.
  • Non-refreshing sleep and difficulties including insomnia and oversleeping.
  • Headaches of a new type or severity
  • Muscular pain, morning stiffness
  • Multi-joint pain (without redness or swelling)
  • Cervical (neck) or axillary (armpit) lymph node tenderness and swelling
  • Sore throat, chronic cough
  • Persistent low-grade fever
  • Problems with short-term memory or concentration. Along with these primary symptoms, people with ME/CFS can also experience:
  • Gastric disturbances including irritable bowel syndrome, diarrhea, nausea.
  • Psychological problems, including depression, irritability, mood swings, anxiety, and panic attacks.
  • Night sweats.
  • Allergies or sensitivities to foods, odors, chemicals, medications or noise.
  • Some people have dizziness, dry eyes or mouth, earaches, irregular heartbeat, jaw pain, shortness of breath, and weight loss.

Diagnostic Criteria

The diagnostic criteria most often used are described in the 1994 International ("Fukuda") Definition for Chronic Fatigue Syndrome. According to that definition, a person is considered to have ME/CFS if he/she has:

1. Unexplained, persistent or relapsing chronic fatigue that is not substantially alleviated by rest, and results in substantial reductions in levels of occupational, educational, social, or personal activities; and

2. Four or more of the following symptoms lasting for six or more consecutive months:

  • Self-reported impairment in short-term memory or concentration
  • Post-exertional malaise (extreme, prolonged exhaustion and a worsening of symptoms following physical or mental exertion)
  • Unrefreshing sleep
  • Muscle pain Multi-joint pain without joint swelling or redness
  • Sore throat Tender neck lymph nodes
  • Headaches of a new type, pattern, or severity.


Since so much about ME/CFS is unknown, the causes of the condition are even more a mystery. Currently there are a few competing ideas, with interactions among these factors under evaluation:

  • Infection: ME/CFS bears some remarkable similarities to other infections, especially mononucleosis. Testing people for Epstein-Barr (EBV), herpesvirus, enterovirus, mycobacterium, rubella, retrovirus, Candida (yeast) have all proved inconclusive. Many sufferers of ME/CFS can relate a story of having an infection or flu-like illness before becoming ill with ME/CFS, but this is not necessarily true with all sufferers.

  • Immune System: Some Researchers believe that ME/CFS is an autoimmune disease similar to lupus, but this has also proven inconclusive. The immune system is affected in many people with ME/CFS as a decrease in immune function; and a propensity to allergic symptoms is also very common among sufferers.

  • Hormonal Imbalance: The most common hormonal problem in ME/CFS sufferers is disruption of the hypothalamic-pituitary-adrenal axis. This hormonal system is responsible for the fight or flight response, typically experienced as anxiety and nervousness. Physical or emotional stressors can cause a dysregulation of this hormonal system, which can lead to further stress and anxiety, a sort of vicious cycle. Constant stress and anxiety can also reduce the immune system function.

  • Hypotension: Many people with ME/CFS have hypotension (low blood pressure). Scientists are puzzled by this low blood pressure and suggest that it may be the result of problems with the nervous system. Hypotension leads to fatigue and tiredness.

  • Nutritional Deficiency: Many people with ME/CFS have nutritional deficiencies, but it is difficult to determine if this is the cause or a result of the disease. Typically, ME/CFS sufferers are low in B-vitamins, magnesium, vitamin D, and many other nutrients.

  • Mitochondrial Dysfunction: Recent Research suggests some factor interfering with the highly complex mechanism of energy production at the cellular level.

  • Central Sensitivity: It is suggested that symptoms of ME/CFS and often-overlapping conditions such as fibromyalgia are manifestations of central nervous system sensitization – “an exaggerated response of the central nervous system [spinal cord and brain] to stimuli.

  • Predisposing Genetic Factors: As suggested by the ongoing gene-expression Research, differences in symptoms experienced and severity may correspond with a number of genomic ME/CFS subtypes.
More than likely, the cause of ME/CFS is the result of a combination of factors, where one factor can affect the other. For example, stress can reduce the effectiveness of the immune system. With a lowered immune system, infection is more likely, and having a chronic infection can lead to more stress. There are many systems in the body that interrelate in similar ways.

Information from excerpts on Prohealth.com. 2010.

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